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Ortho Spore IG, 90 caps

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DESCRIPTION

Ortho Spore IG™ is a spore-based, broad-spectrum probiotic formula designed to promote a healthy gut microflora, protect mucosal integrity, and relieve small intestinal bacterial overgrowth (SIBO). Uniquely included in this formula are serum-derived bovine immunoglobulins that bind to and eliminate microbes and toxins that are common in SIBO.

CLINICAL APPLICATIONS

  • Helps Maintain Normal Gastrointestinal Balance
  • Provides Concentrated Immunoglobulins to Enhance Mucosal Immunity
  • Supports Digestion and Micronutrient Absorption
  • Maintains GI Barrier Health and Integrity


    INGREDIENTS 

    Ingredients: Serum-Derived Bovine Immunoglobulin Concentrate (ImmunoLin®); Bacillus coagulans (SNZ1969); Immunoglobulin G (IgG); Bacillus clausii (B106)  Bacillus subtilis (HS43).

    Other Ingredients: Other  Ingredients:  Microcrystalline  Cellulose,  Hypromellose  (Natural  Vegetable  Capsules) and Silicon Dioxide.

    Does Not Contain:Wheat,   gluten,   soy,   corn,   dairy   products,   fish,   shellfish,   peanuts, tree nuts, egg, artificial colors, artificial sweeteners or preservatives

     

    DIRECTIONS

    Serving Size: 3 Capsules
    Servings Per Container: 30

    Suggested Use: 3 capsules per day or as recommended by your health care professional.

    Cautions:If  you  are  pregnant  or  nursing,  consult  your  physician  before  taking this product.

    Guaranteed potency at expiration. No refrigeration required.

     

    LEARN MORE

    OVERVIEW

    SIBO is a condition that occurs when there is an overabundance of commensal bacteria from the colon present in the small intestine. The health of the small intestines relies on balanced microbiota, and probiotics and immunoglobulins can contribute to that balance by having a positive influence on the intestinal environment, including pH, organism diversity, and immune signaling.

    Probiotics have been extensively studied and are characterized as having broad GI and immune benefits. Probiotics are live organisms and must be shelf stable through the expiration date, so they can be precisely delivered to the intestinal tract to have maximum benefit. Bacillus spores remain dormant in harsh environments until they reach more favorable environments like the human gastrointestinal tract. The combination of specific strains, particularly Bacillus coagulans, Bacillus clausii, and Bacillus subtilis, relieve symptoms for common GI complaints and reinforce healthy gut function.

    In the search for innovative ways to improve microbiome diversity, we have combined our blend of spore-forming probiotics alongside immunoglobulins uniquely shown to bind to bacteria and toxins, driving immune response. IgG helps to maintain a healthy intestinal immune system by binding a broad range of microbes and toxins within the gut lumen.

    INGREDIENT BENEFITS

    Bacillus coagulans:Bacillus coagulans has been shown to increase the commensal GI microbiota. B. coagulans also significantly improved bowel movements in healthy adults with occasional constipation, as well as decreased abdominal discomfort.

    Bacillus clausii:B. clausii is commonly used as a probiotic to promote balance in the microbiome and has showed promising results in individuals with SIBO.

    Bacillus subtilis:Bacillus subtilis has been shown to relieve GI distress in patients.

    Serum-derived bovine immunoglobulins:Broad-spectrum binding capabilities demonstrate the positive influence of serum-derived bovine immunoglobulins. This binding and elimination decreases microbe and toxin encounters by the immune system and resets immune tolerance.

     

    These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.


    References

    1. Dukowicz AC, Lacy BE, Levine GM. Small intestinal bacterial overgrowth: a comprehensive review. Gastroenterol Hepatol (N Y). 2007 Feb;3(2):112-22. PMID: 21960820; PMCID: PMC3099351.
    2. Bures J, Cyrany J, Kohoutova D, Förstl M, Rejchrt S, Kvetina J, Vorisek V, Kopacova M. Small intestinal bacterial overgrowth syndrome. World J Gastroenterol. 2010 Jun 28;16(24):2978-90. doi: 10.3748/wjg.v16.i24.2978. PMID: 20572300; PMCID: PMC2890937.
    3. Soman RJ, Swamy MV. A prospective, randomized, doubleblind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of SNZ TriBac, a three-strain Bacillus probiotic blend for undiagnosed gastrointestinal discomfort. Int J Colorectal Dis. 2019;34(11):1971-1978. doi:10.1007/s00384-019-03416-w
    4. Detzel CJ, Horgan A, Henderson AL, et al. Bovine immunoglobulin/protein isolate binds pro-inflammatory bacterial compounds and prevents immune activation in an intestinal co-culture model. PLoS One. 2015;10(4):e0120278. Published 2015 Apr 1. doi:10.1371/ journal.pone.0120278
    5. Nyangale EP, Farmer S, Cash HA, Keller D, Chernoff D, Gibson GR. Bacillus coagulans GBI-30, 6086 Modulates Faecalibacterium prausnitzii in Older Men and Women. J Nutr. 2015;145(7):1446-1452. doi:10.3945/jn.114.199802
    6. Dolin BJ. Effects of a proprietary Bacillus coagulans preparation on symptoms of diarrhea-predominant irritable bowel syndrome. Methods Find Exp Clin Pharmacol. 2009;31(10):655-659. doi:10.1358/mf.2009.31.10.1441078
    7. Madempudi RS, Neelamraju J, Ahire JJ, Gupta SK, Shukla VK. Bacillus coagulans Unique IS2 in Constipation: A DoubleBlind, Placebo-Controlled Study. Probiotics Antimicrob Proteins. 2020;12(2):335-342. doi:10.1007/s12602-019- 09542-9
    8. Gabrielli M, Lauritano EC, Scarpellini E, Lupascu A, Ojetti V, Gasbarrini G, Silveri NG, Gasbarrini A. Bacillus clausii as a treatment of small intestinal bacterial overgrowth. Am J Gastroenterol. 2009 May;104(5):1327-8. doi: 10.1038/ ajg.2009.91. Epub 2009 Apr 7. PMID: 19352343.

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