Glutathione is the master antioxidant in the body and is heavily concentrated in tissues such as the liver, spleen and heart. Therefore, it plays a crucial role in immune function, detoxification capacity and protection against oxidative stress. The L-Glutathione formulation is preformed, reduced glutathione (GSH) and provides a 250 mg dose in a one-capsule serving.
Supports healthy immune system function
Supports the liver’s natural detoxification processes
Neutralizes free radicals
Ingredients: L-Glutathione (Reduced) (Setria®)
Other Ingredients: Natural Vegetable Capsules, Microcrystalline Cellulose, Magnesium Stearate, and Silicon Dioxide
Formulated to be free of allergens derived from: Gluten, corn, yeast, artificial colors and flavors.
Serving Size: 1 capsule Servings per container: 60
Suggested use: 1 capsule per day or as recommended by your healthcare professional.
Modern lifestyle habits like poor dietary choices, lack of sleep, abundance of stress, exposure to chemicals, and exercise extremes can incur physiologic changes. Our bodies were designed to handle stress, detoxify chemicals and preserve cell function, but when the burden increases, those naturally built-in systems can’t keep up with demand. One of the most common physiological changes seen is the depletion of the body’s most powerful antioxidant, reduced glutathione. Glutathione has been termed “the master antioxidant” because of its ability to quench free radicals and protect cells from damage. It has long been thought that humans were unable to utilize preformed glutathione, but recent research proves otherwise. Setria®, a unique tri-peptide form of glutathione, has a molecular structure that effectively increases glutathione blood levels when taken orally. It is the only supplemental glutathione backed by a recently published human clinical trial that shows significant uptake of this critical nutrient.
Glutathione and Detoxification
Because of glutathione’s central role in detoxification, about 25% of all glutathione resides in the liver. Glutathione is more than simply an electron donor; glutathione plays an important role in protecting living cells from toxicity by detoxifying the reactive intermediates via enzymatic conjugation.
Glutathione and Immune Health
It is well known that the gastrointestinal cells, the mitochondria and the efficiency of immune cell function are three major factors in immune function. Glutathione happens to play a role in all three elements. When small intestinal mucosa atrophies, it causes an increase in epithelial permeability and compromised tight junctions, which can lead to translocation of bacteria. This translocation of bacteria is implicated in immune activation and autoimmunity. Studies have shown that this epithelial damage is in part due to the inability to mitigate reactive oxygen species (ROS). Supplementing with oral glutathione under conditions in which intracellular glutathione status is compromised can restore tissue glutathione and promote ROS metabolism, thereby mitigating tissue atrophy, according to a 2017 study published in the World Journal of Gastroenterology.
Statements contained herein have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent disease.
1. Richie JP, Nichenametla S, Neidig W, et al. Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. Eur J Nutr. 2015;54(2):251-263.
2. Ketterer B, Coles B, Meyer DJ (1983). The role of glutathione in detoxication. Environ Health Perspect, 49:59-69.
3. P. S. Samiec, L. J. Dahm, D. P. Jones, Glutathione S-Transferase in Mucus of Rat Small Intestine, Toxicological Sciences, Volume 54, Issue 1, March 2000, Pages 52–59, https://doi. org/10.1093/toxsci/54.1.52
4. Uchida H, Nakajima Y, Ohtake K, et al. Protective effects of oral glutathione on fasting-induced intestinal atrophy through oxidative stress. World J Gastroenterol. 2017;23(36):6650–6664. doi:10.3748/wjg.v23.i36.6650
5. Morris D, Ly J, Chi PT, et al. Glutathione synthesis is compromised in erythrocytes from individuals with HIV. Front Pharmacol. 2014;573.
6. Rushworth GF, Megson IL. Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits. Pharmacol Ther. 2014;141(2):150-159.
7. Sido B, Hack V, Hochlehnert A, Lipps H, Herfarth C, Dröge W. Impairment of intestinal glutathione synthesis in patients with inflammatory bowel disease. Gut. 1998;42(4):485-492.
8. Witschi A, Reddy S, Stofer B, Lauterburg BH. The systemic availability of oral glutathione. Eur J Clin Pharmacol. 1992;43(6):667-669.
9. Allen J, Bradley RD. Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteers. J Altern Complement Med. 2011;17(9):827-833.
10. Ballatori N, Krance SM, Notenboom S, Shi S, Tieu K, Hammond CL. Glutathione dysregulation and the etiology and progression of human diseases. Biol Chem. 2009;390(3):191-214.