Methyl B Complex is formulated with eight essential B vitamins, choline, inositol, and folate to support energy production, and immune, cardiovascular and neurological health.
Provides Baseline Nutrition for a Variety of Protocols
Builds Metabolic Reserve and Protects Against Dietary Deficiencies
Protects Against Stress-Induced Nutrient Depletion
Supports Healthy Metabolism
A wide and complex variety of B vitamins is essential for the body to convert food into cellular energy. These water-soluble groups of vitamins are first absorbed in the small intestine and then travel to the liver where they are biotransformed into their active coenzyme forms. One of the key roles of B vitamins is to serve as prime coenzymes for the Kreb’s cycle, the biochemical pathway responsible for maintaining energy production. In addition, B vitamins, particularly folate, B6 and B12 are critical for proper methylation, a biochemical process that helps convert the problematic amino acid metabolite homocysteine into the amino acids methionine and cysteine. This process is vital for supporting cardiovascular and mental health, a healthy nervous system, regulating gene expression, proper energy metabolism, as well as immune and nerve cell function. Additional intake of B vitamins is often needed by individuals with high levels of stress.
Other Ingredients: Natural Vegetable Capsules, Magnesium Stearate, and Silicon Dioxide
Does Not Contain: gluten, corn, yeast, artificial colors and flavors
Serving Size: 1 capsule Servings per container: 60
Directions: One or more capsules per day or as recommended by your health care professional.
Cautions:If you are pregnant or nursing, consult your physician before taking this product
Folate is a water soluble member of the B complex vitamins that is critical for maintaining optimal methylation. Folate is found naturally in foods such as fruits and dark leafy vegetables, but can be easily destroyed by cooking or processing. Additionally, enzyme defects, malabsorption and congenital deficiency of 5-methylenetetrahydrofolate reductase (5-MTHFR), an enzyme required for the conversion of folic acid to its bioactive form 5-methyltetrahydrofolate (5-MTHF), can result in an impaired ability to activate folic acid. In individuals with a genetic defect of this enzyme, supplementation with 5-MTHF has been shown to be beneficial. 5-MTHF is required as a methyl group donor for the production of mood regulating neurotransmitters such as serotonin, the synthesis of melatonin, as well as DNA production and repair.
Thiamine (Vitamin B1)
While naturally abundant in whole grains, thiamine is lost in many of the over-processed grains commonly consumed today. Thiamine is an essential co-factor in the production of ATP in the cells’ Kreb's cycle, and is also needed for the metabolism of fats, proteins and carbohydrates.
Riboflavin (Vitamin B2)
Riboflavin is a precursor to flavin adenine dinucleodtide (FAD) and flavin mononucleotide (FMN), both of which are central to energy production, intermediary metabolism, and act as powerful antioxidants. Riboflavin-depleted cells have been found to display signs of greater oxidative stress and disrupted energy generation.
Niacin is a cofactor in the mitochondrial respiratory chain, which produces cellular energy. In the body, niacin is transformed into NAD (nicotinamide adenine dinucleotide) and NADP (nicotinamide adenine dinucleotide phosphate), which both play a role in oxidation reduction reactions in cells.
Vitamin B6 is involved in over 100 enzymatic reactions in the body and is essential for gluconeogenesis, lipid metabolism, neurotransmitter formation, immune health and hormone modulation, and is essential in methylation, for the breakdown of homocysteine.
Vitamin B12 (Methylcobalamin)
Vitamin B12, found only in organ meats, seafood and egg yolks, often becomes deficient in vegan and vegetarian diets. The vitamin is essential for the metabolism of fats and carbohydrates, the synthesis of proteins, and also plays a role in regulating mitochondrial enzymes and energy metabolism, as well as neurological health.
Synthesized by the bacteria in the gut and in certain foods, biotin and its cofactors are involved in metabolism of fatty acids, amino acids and the utilization of B vitamins.
Pantothenic acid and its biologically active derivative, CoA, are essential to the synthesis of fatty acids, membrane phospholipids, amino acids, steroid hormones, and energy production.
Though not technically a B vitamin, choline is often associated with the B vitamin complex. It is important in the construction of cell membranes and plasma lipoproteins, plays a role in cell signaling and in the synthesis of acetylcholine (a neurotransmitter), and is vital for brain development.
Statements contained herein have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent disease.
1. 5-methyltetrahydofolate. Altern Med Review 2006; 11(4).
2. Rindi G. Thiamin. In: Ziegler E, Filer LJ, eds. Present Knowledge in Nutrition. International Life Sciences Institute. 1996:160-166.
3. Thiamine. Monograph. Altern Med Rev. Feb 2003;8(1):59-62.
4. Alaei Shahmiri F, Soares MJ, Zhao Y, Sherriff J. High-dose thiamine supplementation improves glucose tolerance in hyperglycemic individuals: a randomized, double-blind crossover trial. Eur J Nutr. 2013 Oct;52(7):1821-4. Epub 2013 May 29.
5. Rivlin R. Riboflavin. In: Ziegler E, Filer LJ, eds. Present Knowledge in Nutrition: International Life Sciences Institute. 1996:167-173.
6. Lee ES, Corfe BM, Powers HJ. Riboflavin depletion of intestinal cells in vitro leads to impaired energy generation and enhanced oxidative stress. Eur J Nutr. 2013 Aug;52(5):1513-21. Epub 2012 Nov 6.
7. Wilson CP, Ward M, McNulty H, Strain JJ, Trouton TG, Horigan G, Purvis J, Scott JM. Riboflavin offers a targeted strategy for managing hypertension in patients with the MTHFR 677TT genotype: a 4-y follow-up. Am J Clin Nutr. 2012 Mar;95(3):766-72. Epub 2012 Jan 25.
8. Huskisson E, Maggini S, Ruf M. The role of vitamins and minerals in energy metabolism and well-being. J Int Med Res. May-Jun 2007;35(3):277-289.
9. Sahebkar A. [Epub ahead of print] Effect of niacin on endothelial function: A systematic review and meta-analysis of randomized controlled trials. Vasc Med. 2014 Jan 3.
10. Mason CM, Doneen AL. Niacin-a critical component to the management of atherosclerosis: contemporary management of dyslipidemia to prevent, reduce, or reverse atherosclerotic cardiovascular disease. J Cardiovasc Nurs. 2012 JulAug;27(4):303-16.